Convalescent plasma in Covid-19: Possible mechanisms of action
Rojas, Manuel | 2020-07
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is responsible of the coronavirus disease 2019(COVID-19) pandemic. Therapeutic options including antimalarials, antivirals, and vaccines are under study.Meanwhile the current pandemic has called attention over old therapeutic tools to treat infectious diseases.Convalescent plasma (CP) constitutes thefirst option in the current situation, since it has been successfully usedin other coronaviruses outbreaks. Herein, we discuss the possible mechanisms of action of CP and their re-percussion in COVID-19 pathogenesis, including direct neutralization of the virus, control of an overactiveimmune system (i.e., cytokine storm, Th1/Th17 ratio, complement activation) and immunomodulation of ahypercoagulable state. All these benefits of CP are expected to be better achieved if used in non-criticallyhospitalized patients, in the hope of reducing morbidity and mortality.