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La autopsia molecular en la muerte súbita cardiaca

Bonilla, Juan Carlos; Parra-Medina, Rafael; Chaves, Juan José; Campuzano, Oscar; Sarquella-Brugada, Georgia; Brugada, Ramón; Brugada, Josep (Instituto Nacional de Cardiología Ignacio ChávezMéxico, 2018-06)

Actualmente hay un porcentaje importante de autopsias que quedan sin un diagnóstico concluyente del fallecimiento, especialmente cuando este evento letal se produce súbitamente. El análisis genético se ha ido incorporando ...
Review of clinical non-medico-legal autopsy: a descriptive study in 747 patients

Mendoza, Oscar; Bonilla, Juan Carlos; Moreno, Liliana; Piedrahita, Carolina; Mosquera, Andrés; Parra Medina, Rafael (Autoridad de Medicina Forense de EgiptoEgipto, 2018-12)

Background: Autopsies have been an essential element to healthcare professionals’ training, as well as to research processes, education, and public health. In spite of the decline of clinical autopsy rate after the Joint ...

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La autopsia molecular en la muerte súbita cardiaca
...
Bonilla, Juan Carlos | 2018-06

Actualmente hay un porcentaje importante de autopsias que quedan sin un diagnóstico concluyente del fallecimiento, especialmente cuando este evento letal se produce súbitamente. El análisis genético se ha ido incorporando recientemente al campo de la medicina forense, sobre todo en aquellos pacientes que han fallecido de forma repentina, y donde no se identifica causa concluyente del fallecimiento tras una autopsia médico-legal completa. En estos casos las enfermedades eléctricas primarias son las principales responsables del fallecimiento. Hasta la fecha se han descrito más de 40 genes asociados a afecciones arritmogénicas causantes de muerte súbita cardiaca. Las principales enfermedades arritmogénicas son el síndrome de QT largo y la taquicardia ventricular; estudios genéticos post-mortem no solo permiten llevar a cabo un diagnóstico de la causa del fallecimiento, sino que también permiten una traslación clínica hacia los familiares, focalizado en la identificación precoz de individuos en riesgo de síncope, así como adopción de medidas terapéuticas personalizadas para la prevención de un episodio arrítmico letal.

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Review of clinical non-medico-legal autopsy: a descriptive study in 747 patients
...
Mendoza, Oscar | 2018-12

Background: Autopsies have been an essential element to healthcare professionals’ training, as well as to research processes, education, and public health. In spite of the decline of clinical autopsy rate after the Joint Commission on the Accreditation of Hospitals eliminated the minimum autopsy rate required for accrediting hospitals, in Colombia, South America, we have seen that this practice has been reinitiated and our institution has performed more than 200 autopsies per year. Objective: To describe the main causes of death among individuals to whom a clinical autopsy was practiced at a general hospital in Bogotá, Colombia. Methods: A descriptive study of autopsy reports during the period between January 2012 and June 2015 was conducted. Results: The study included 747 autopsies of which 58.2% were performed in males. The majority of deaths occurred among the 41 to 64 years (mean 32.53, SD 28.53) age group. The leading cause of death observed in young adults and middle-aged adults (18 to 64 years) was cardiac arrest (58.5%) associated with acute myocardial infarction, cardiomyopathies, or cardiovascular abnormalities, followed by respiratory conditions (42.6%) and cardiac sudden death as the second cause of death in young adults. Conclusions: Studies based on clinical autopsies allow precise knowledge on the main underlying causes of death in a population, as well as, enable ideas based on key data obtained to be used in the development of cardiovascular prevention strategies for the different age groups thus preventing fatal outcomes in young adults who are the active working, productive population in society.

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