Morbidity and mortality associated with performing bone marrow aspiration and biopsy
Patiño, Bonell | 2018-02-06
Background: Bone marrow aspiration and biopsy are diagnostic methods in the
study of hematological diseases. Complications are rare. Knowing the morbidity
and mortality related to the procedure is essential in order to implement preventive
behaviors and improvement plans.
Objective: To determine the incidence of complications in patients over 18 years
who were undergone to bone marrow biopsy and aspiration in a university hospital
between October 2013 and May of 2015. Furthermore, frequency, socio-demographic
and clinical characteristics were established as well.
Materials & methods: Observational, descriptive and retrospective study. The unit
of analysis was biopsies and bone marrow aspirations. The information was obtained
from the database of outpatient hematology ward, into the program Group of Education
and Monitoring of Egress (GESE) of the Hematology Service of Hospital de San José
(Bogotá, Colombia), and from medical records.
Results: A total of 1252 bone marrow aspirates and biopsies were performed on 914
patients. Seventy-seven complications were reported, which corresponds to 6.15% of
all documented procedures. The most frequent complication was: pain (100%), being
more affected the women (66%), OR 1,91(IC 1,18-3,11) p=0,003. Regard to pathology
diagnosis, 53.2% of biopsies were histologically normal hematopoiesis, followed
by 16.8% for chronic myeloproliferative syndromes, which was the diagnosis most
commonly associated with bleeding events (40%):OR 8,9 (IC 1,2-66,44) p=0,006, and
Conclusion: Pain was the most frequently reported complication, and among bleeding
complications, chronic myeloproliferative disorders were the most common diagnosis.
The largest number of complications in women may be related to the anatomical
differences between the genders. It is recommended to improve post-procedure
analgesia and prospective studies to establish association between complications and