Ganglio centinela en carcinoma escamocelular cutáneo del tronco y extremidades: experiencia en un centro de referencia latinoamericano
Díaz Casas, Sandra | 2016-06-09
Objective: To describe the clinical, histopathological and surgical treatment characteristics of patients with squamous cell carcinoma skin of the trunk and extremities, carried sentinel node at the National Cancer Institute in the period 1 January 2007 through 30 December 2013.
Methods: A descriptive study of historical cohort study was conducted. Patients with confirmed squamous cell carcinoma of the trunk and extremities diagnosis, which underwent surgical management of the primary lesion and sentinel node biopsy, by the service within soft tissues of the institution and between January 1, 2007 to December 30, 2013. They were excluded patients diagnosed with squamous cell carcinoma of anogenital origin.
Results: 60 clinical histories, pathology results from sentinel node was negative for SCC in 81 % (n = 49) patients, positive in 15 % (n = 9) and no diagnosis in 3 % ( n = 2); 40 % (n = 24) of patients had clinical examination palpable lymphadenopathy, of which only 4 patients had positive sentinel node. Mean subsequent relapse free survival surgical treatment in patients with positive sentinel node was 8.3 months (95 % CI 5.0 to 11.5 months) vs 58.6 months (95 % CI 47.8 to 69.3 months) in patients with negative sentinel node. Only 4 (8.1 %) of 49 patients with negative sentinel node, showed regional relapse.
Conclusions: The sentinel node in SCC trunk and extremities, is a suitable instrument staging of nodal chain , with a low rate of associated complications. Similarly, a high percentage of locoregional was found in patients with positive sentinel node, in contrast to that presented negative results , which opens the door to new prospective cohort studies that can demonstrate statistically significant differences were found