Asociación de obesidad y dislipidemia con el riesgo de progresión a deterioro cognitivo leve y demencia: revisión sistemática
Pedraza Linares, Olga Lucía | 2018-02-02
Objective: This study seeks to identify if there is a relationship between obesity or dyslipidemia and cognitive impairment in adults older tan 65 years described in the literature Methods: We searched the scientific literature published in PubMed, EbscoHost, ScienceDirect ClinicalKey and Cochrane Registry, for the years 2009 to 2017, of prospective cohort studies and cases and controls of adult subjects with a diagnosis of obesity or dyslipidemia and with assessments of cognitive function over time, in order to determine the incidence of MCI and Dementia and its relation to the mentioned risk factors. Results: This systematics review showed a total of 13 high quality articles according to SIGN, which met the selection criteria for the objectives of the review. Of the articles selected, 7 include as risk factor obesity and 6 dyslipidemia. In the different articles related to obesity in older adults, it was reported that there is no direct relationship between obesity and cognitive impairment, as in the different articles related to dyslipidemia there was no direct relationship with cognitive impairment. Conclusion: Elderly patients with obesity, may have a protective factor against the development of cognitive impairment, which does not occur with young adults. On the other hand, the pathophysiology described in dyslipidemia suggests that high and low cholesterol can lead to DCL and dementia.