Envíos recientes

Afinidad entre las pruebas PCR y Antígeno, y su positivad para COVID-19 en Colombia

Díaz Pinzón, Jorge Enrique | 2021-03-08

Análisis de datos en el estudio del COVID-19 en Colombia

Díaz Pinzón, Jorge Enrique | 2020-04-06

Asociación del grupo sanguíneo ABO con complicaciones en covid-19 : revisión sistemática y meta-análisis.

Nieto Zambrano, Paula Daniela | 2022-04-05

Características clínicas y sociodemográficas de pacientes fallecidos por COVID-19 en Colombia

Carcamo Molina, Luis Miguel | 2020-04-06

Cálculo de razón y proporcionalidad de personas contagiadas y recuperadas por COVID-19 en Colombia

Díaz Pinzón, Jorge Enrique | 2020-04-06

Cobertura de vacunación contra COVID-19 por esquema en Colombia

Díaz Pinzón, Jorge Enrique | 2021-03-08

Colchicine: A potential therapeutic tool against COVID-19. Experience of 5 patients

Montealegre Gómez, Giovanni | 2020-05-16

COVID-19 is a newly emerged disease that has become a global public health challenge. Due to a lack of knowledge about the virus, a significant number of potential targets for using a particular drug have been proposed. Five cases with a clinical history of biopolymers in the gluteal region that developed iatrogenic allogenosis (IA) are presented here. The 5 cases were put under colchicine treatment for IA crisis and had non-specific symptoms (headache, cough without dyspnea, and arthralgias) with a positive SARSCoV-2 test. Their close contacts had mild to severe symptoms and three of them died. In the SARS-CoV-2 infection different inflammatory pathways are altered where colchicine reduces cytokine levels as well as the activation of macrophages, neutrophils, and the inflammasome. The possible mechanisms that colchicine may use to prevent acute respiratory distress syndrome (ARDS) in patients with COVID-19 infection are also reviewed in this article.

Comments to: A systematic review of pathological findings in COVID-19: a pathophysiological timeline and possible mechanisms of disease progression

Parra Medina, Rafael | 2020-07

We reviewed the excellent systematic article published by Pola et al. [1] about the pathological findings in COVID-19. Based on the 250 COVID-19 autopsies found during our systematic review through March 30, 2020; we concur with the article hypothesis of mechanisms of infection and the tissular injury. However, we would like to highlight two topics that the authors did not discuss. The first, the autopsies findings could support the hypothesis of macrophages hyperactivation. This has already been reported in other coronavirus such as SARS-CoV1 and MERS [2]. In the initial autopsies in COVID-19 patients, the presence of CD68+ macrophages in lung and heart tissues [3, 4] and the presence of CD169+ macrophages in lymph node subcapsular spaces and in splenic marginal zone were reported. These macrophages expressed the SARS-CoV-2 entry receptor ACE2 and contained SARS-CoV-2 nucleoprotein [5]. Disorders of macrophages as secondary hemophagocytic lymphohistiocytosis (sHLH) have been reported in COVID-19 . In autopsies, hemophagocytosis has been observed in lung, lymph node, bone marrow, liver, and spleen . sHLH is a hyperinflammatory syndrome characterized by a fulminant and fatal hypercytokinaemia with multiorgan failure. In adults, sHLH is mostly triggeredby viral infections, autoimmune diseases and neoplasms [11], and occurs in 3.7–4.3% of sepsis cases [12]. The diagnosis of sHLH is based on clinical, laboratory, and morphologic criteria. The main features are: unremitting fever, cytopenias, hepatosplenomegaly, hypertriglyceridemia, hypofibrinogenemia, and hyperferritinemia. Severe COVID-19 could be considered a hyperferritinemic syndrome by the clinical similarities detected . In these conditions, Ferritin plays a critical role in the immune response. The production and secretion of extracellular ferritin is derived from macrophages.

Comorbilidades de los fallecidos por COVID-19 según el grupo etario en Colombia

Díaz Pinzón, Jorge Enrique | 2020-04-06

Condiciones de vulnerabilidad, sociodemográficas y clínicas de la población diagnosticada con COVID-19 incluida en la estrategia de atención primaria en salud del municipio de Mosquera 2020

López Guzmán, Yudy Carolina | 2022-04-05

Conglomerados que favorecen la transmisión del COVID-19 en Colombia

Díaz Pinzón, Jorge Enrique | 2020-04-06

Consenso colombiano de atención, diagnóstico y manejo de la infección por sars-cov-2/COVID 19 en establecimientos de atención de la salud. Recomendaciones basadas en consenso de expertos e informadas en la evidencia

Abello, Virginia | 2020

La Asociación Colombiana de Infectología (ACIN) y el Instituto de Evaluación de Nuevas Tecnologías de la Salud (IETS) conformó un grupo de trabajo para desarrollar recomendaciones informadas y basadas en evidencia, por consenso de expertos para la atención, diagnóstico y manejo de casos de Covid 19. Estas guías son dirigidas al personal de salud y buscar dar recomendaciones en los ámbitos de la atención en salud de los casos de Covid-19, en el contexto nacional de Colombia.

Contagios, recuperados y fallecidos por SARS-COV-2 quinientos días después del primer reporte en Colombia

Díaz Pinzón, Jorge Enrique | 2021-03-08

Continuidad con los procesos pedagógicos de los estudiantes durante la pandemia ocasionada por el COVID-19

Díaz Pinzón, Jorge Enrique | 2020-04-06

Convalescent plasma in Covid-19: Possible mechanisms of action

Rojas, Manuel | 2020-07

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is responsible of the coronavirus disease 2019(COVID-19) pandemic. Therapeutic options including antimalarials, antivirals, and vaccines are under study.Meanwhile the current pandemic has called attention over old therapeutic tools to treat infectious diseases.Convalescent plasma (CP) constitutes thefirst option in the current situation, since it has been successfully usedin other coronaviruses outbreaks. Herein, we discuss the possible mechanisms of action of CP and their re-percussion in COVID-19 pathogenesis, including direct neutralization of the virus, control of an overactiveimmune system (i.e., cytokine storm, Th1/Th17 ratio, complement activation) and immunomodulation of ahypercoagulable state. All these benefits of CP are expected to be better achieved if used in non-criticallyhospitalized patients, in the hope of reducing morbidity and mortality.

Correlación entre las pruebas PCR y Antígeno y el contagio por COVID-19 en Colombia

Díaz Pinzón, Jorge Enrique | 2021-03-08

Covid 19: manifestaciones neurológicas

Vergara, Jean Paul | 2020-05-03

La enfermedad por coronavirus 2019 (covid-19) puede ser clasificada en asintomática, leve, moderada, grave y crítica de acuerdo con los síntomas respiratorios. En 36% de los casos pueden presentarse manifestaciones en el sistema nervioso central, periférico y musculoesquelético. En algunos países el acceso a la unidad de cuidados intensivos ha sido limitado, generado dilemas éticos.

Covid-19 : Herramientas de prevención actual en las unidades de endoscopia

Jaramillo Trujillo, Maria Andrea | 2020-04-06

COVID-19 en Colombia: un año después de confirmar su primer caso

Díaz Pinzón, Jorge Enrique | 2021-03-08

Criptococosis diseminada en paciente positivo para COVID-19

Restrepo, Héctor Fabio | 2021-03-08