Clinical Effectiveness and Safety of Treatment With Anti–Tumor Necrosis Factor α Drugs in a Cohort of Colombian Patients With Rheumatoid Arthritis
Objective: To compare the clinical response at 24 months and evaluate
the adverse events (AEs) of patients with rheumatoid arthritis (RA) treated
with etanercept 50 (injectable solution 50 mg prefilled syringe), etanercept
25 (lyophilized 25 mg), infliximab, adalimumab, or golimumab.
Methods: A cohort study was carried out in patients with RA, in treatment with etanercept (injectable solution 50 mg prefilled syringe or lyophilized 25 mg), infliximab, adalimumab, or golimumab. Duration of study:
follow-up was carried out for 24 months. The difference of initial and final
28-joint Disease Activity Score, remission incidence, difference of initial
and final Health Assessment Questionnaire score, disability recovery, and
AE rate were evaluated.
Results: The study enrolled 435 patients (108 adalimumab, 107 infliximab,
92 etanercept 25 mg, 81 etanercept 50 mg, and 47 golimumab). For etanercept
50, the median difference between basal and at the end of follow-up 28-joint
Disease Activity Score was 1.7. For golimumab, it was 1.4; for adalimumab,
it was 1.1; for etanercept 25, it was 1.02; and for infliximab, it was 0.96
(p = 0.001). The median difference between basal and final Health Assessment
Questionnaire ranged was 1.66 for etanercept 50, 1.34 for etanercept 25, 1.3
for golimumab, 1.24 for adalimumab, and 1.07 for infliximab (p = 0.0005).
Comparatively, etanercept 50 presented the highest cumulative incidence
(77%; 95% confidence interval [CI], 67%–86%) and remission incidence
(64 cases per 100 person-months; 95% CI, 4.9–8.1 cases per 100 personmonths) and the lowest AE rate (8.6 per 100 person-years; 95% CI, 5.3–15
per 100 person-years).
Conclusions: In patients with RA treated with anti–tumor necrosis factor
α drugs, the highest incidence of remission and the lowest