Prescription Profile and Clinical Outcomes in Patients with Allergic Rhinitis Treated with Oral Antihistamines or Nasal Corticosteroids
Sánchez, Guillermo | 2019-04
Introduction Oral antihistamines and intranasal corticosteroids have been shown to
be effective and safe for the treatment of allergic rhinitis; however, the evidence
suggests a level of superiority of corticosteroids, so they should be preferred over the
Objective To know the prescription profile of two second generation antihistamines
(cetirizine and levocetirizine) and two nasal corticosteroids (mometasone and furoateciclesonide) in a cohort of patients with allergic rhinitis, and to compare the clinical
Methods A cohort study was carried including patients with allergic rhinitis treated
with cetirizine, levocetirizine, mometasone furoate or ciclesonide. The improvement
was evaluated with the total nasal symptoms score (TNSS). This scale yields results
between 0 and 12. Zero indicates absence of symptoms.
Results A total of 314 patients completed 12 weeks of follow-up. Seventy-five percent
were treated with antihistamines, 20% with corticosteroids, and 5% with a combination
of the above. The TNSS median for corticosteroid was 2.5 points; for antihistamines, its
was 5 points, and for combination, it was 4 points. We found differences between
corticosteroids and antihistamines.
Conclusion The prescription percentage of second generation oral antihistamines is
higher than that of intranasal corticosteroids. However, patients with allergic rhinitis
treated with the second option obtained better control of symptoms.