Importancia de la orientación diagnóstica en hemofilia A adquirida
Artículo de revista
2019-03
Sociedad Médica de Santiago
Revista Médica de Chile
147
334
341
Acquired hemophilia A (AHA) is a rare and life-threatening autoimmune
hemorrhagic disorder where autoantibodies are developed against factor VIII. An
early diagnosis is challenging and mandatory: an immediate hemostatic control
is required to reduce morbidity and mortality. Laboratory features of AHA
are: presence of autoantibodies against factor VIII, prolonged activated partial
thromboplastin time (with normal prothrombin time and thrombin time) and
decreased factor VIII levels. In some cases, the results of laboratory tests may
be incorrect due to errors in analysis, blood extraction or manipulation of samples; also worth of consideration are limitations in the measurement range and
low sensitivity of the tests. This review highlights the importance of adequate
screening in patients with suspected AHA to make an adequate diagnosis and
reduce overall fatal outcomes
- Artículos [30]
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