Persona: Parra-Medina, Rafael
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Parra-Medina
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Rafael
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0000-0002-8428-5837
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Publicación Acceso abierto Neuroendocrine neoplasms of gastrointestinal tract and secondary primary synchronous tumors: A systematic review of case reports. Casualty or causality?(San Francisco CA., 2019-05) Moreno Lucero, Paula; Jimenez Moreno, Julián; Parra Morales, Alexandra María; Romero Rojas, Alfredo; Parra-Medina, RafaelNeuroendocrine neoplasms (NENs) can arise in most of the epithelial organs of the body and are not a rare condition in the gastrointestinal tract (GIT). The presence of NENs in GIT associated with other secondary primary malignancies (SPM) has been considered an exotic event. This study aims to describe the case reports of NENs accompanied by synchronous primary tumors.Publicación Acceso abierto Colonic adenosquamous carcinoma and mucinous adenocarcinoma with microsatellite instability(College of Pathologists, 2018) López Correa, Patricia; Gutiérrez, Víctor; Polo, José Fernando; Parra-Medina, RafaelA 43-year-old man presented with two-month history of fatigue, weakness, paleness, rectal bleeding, sweating, and weight loss of 10 kg in the past one month. A complete blood count revealed anaemia. The patient underwent a right hemicolectomy. The microscopic examination revealed an adenosquamous carcinoma associated with a mucinous adenocarcinoma in a patient with microsatellite instability due to loss of MLH1 and PMS2 expression and retention of MSH2 and MSH6 expression in both the squamous and glandular components. We also observed an atypical immunohistochemical phenotype in the adenocarcinoma component showing CK7 expression and reduced CK20 and CDX2 expressionPublicación Acceso abierto Carcinosarcoma with choriocarcinomatous and osteosarcomatous differentiation in a patient with juvenile polyposis syndrome(Publicaciones SAGE, 2015-09-01) López Correa, Patricia; Jiménez Moreno, Julián; Moreno Lucero, Paula; Yaspe, Edgardo; Polo Nieto, José Fernando; Parra-Medina, RafaelJuvenile polyposis syndrome (JPS) is an infrequent autosomal dominant hereditary predisposition to the occurrence of hamartomatous polyps in the colon and rectum. We describe the case of a 12-year-old boy with JPS associated with an abdominal tumor. Histological sections of the abdominal tumor showed components of adenocarcinoma, osteosarcoma, and choriocarcinoma. Immunohistochemistry was AE1/AE3, CK7, HCG and SALL4 positive. Juvenile polyposis syndrome patients are at increased risk of colorectal adenocarcinoma. However, we present a case of an adenocarcinoma associated with other unusual components. This association has not been reported before.