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Comments to: A systematic review of pathological findings in COVID-19: a pathophysiological timeline and possible mechanisms of disease progression

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dc.contributor.authorParra Medina, Rafael
dc.contributor.authorHerrera, Sabrina
dc.contributor.authorMejía, Jaime
dc.date.accessioned2022-04-18T19:34:54Z
dc.date.available2022-04-18T19:34:54Z
dc.date.issued2020-07
dc.description.abstractWe reviewed the excellent systematic article published by Pola et al. [1] about the pathological findings in COVID-19. Based on the 250 COVID-19 autopsies found during our systematic review through March 30, 2020; we concur with the article hypothesis of mechanisms of infection and the tissular injury. However, we would like to highlight two topics that the authors did not discuss. The first, the autopsies findings could support the hypothesis of macrophages hyperactivation. This has already been reported in other coronavirus such as SARS-CoV1 and MERS [2]. In the initial autopsies in COVID-19 patients, the presence of CD68+ macrophages in lung and heart tissues [3, 4] and the presence of CD169+ macrophages in lymph node subcapsular spaces and in splenic marginal zone were reported. These macrophages expressed the SARS-CoV-2 entry receptor ACE2 and contained SARS-CoV-2 nucleoprotein [5]. Disorders of macrophages as secondary hemophagocytic lymphohistiocytosis (sHLH) have been reported in COVID-19 . In autopsies, hemophagocytosis has been observed in lung, lymph node, bone marrow, liver, and spleen . sHLH is a hyperinflammatory syndrome characterized by a fulminant and fatal hypercytokinaemia with multiorgan failure. In adults, sHLH is mostly triggeredby viral infections, autoimmune diseases and neoplasms [11], and occurs in 3.7–4.3% of sepsis cases [12]. The diagnosis of sHLH is based on clinical, laboratory, and morphologic criteria. The main features are: unremitting fever, cytopenias, hepatosplenomegaly, hypertriglyceridemia, hypofibrinogenemia, and hyperferritinemia. Severe COVID-19 could be considered a hyperferritinemic syndrome by the clinical similarities detected . In these conditions, Ferritin plays a critical role in the immune response. The production and secretion of extracellular ferritin is derived from macrophages.eng
dc.format.extent2 p.spa
dc.format.mimetypeapplication/pdfspa
dc.identifier.eissn1530-0285spa
dc.identifier.issn0893-3952spa
dc.identifier.urihttps://repositorio.fucsalud.edu.co/handle/001/2695
dc.language.isoengspa
dc.publisherNature Pub. Grupospa
dc.publisher.placeEstados Unidosspa
dc.relation.citationendpage1609spa
dc.relation.citationstartpage1608spa
dc.relation.citationvolume34spa
dc.relation.ispartofModern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc
dc.relation.ispartofjournalModern pathology : an official journal of the United States and Canadian Academy of Pathology, Incspa
dc.rights.accessrightsinfo:eu-repo/semantics/openAccessspa
dc.rights.coarhttp://purl.org/coar/access_right/c_abf2spa
dc.rights.creativecommonsAtribución-NoComercial-SinDerivadas 4.0 Internacional (CC BY-NC-ND 4.0)spa
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/4.0/spa
dc.sourcehttps://www.nature.com/articles/s41379-020-0631-z.pdfspa
dc.subject.decsMédula ósea
dc.subject.decsCorazón
dc.subject.decsHeridas y lesiones
dc.subject.decsTejidos
dc.subject.decsRevisión sistemática
dc.subject.decsCarta
dc.subject.decsAutopsia
dc.subject.decsAdulto
dc.subject.proposalCOVID-19eng
dc.subject.proposalAutopsyeng
dc.subject.proposalAdulteng
dc.subject.proposalSystematic revieweng
dc.subject.proposalTissueseng
dc.subject.proposalWounds and injurieseng
dc.subject.proposalCoronaviruseng
dc.subject.proposalHearteng
dc.titleComments to: A systematic review of pathological findings in COVID-19: a pathophysiological timeline and possible mechanisms of disease progressioneng
dc.typeArtículo de revistaspa
dc.type.coarhttp://purl.org/coar/resource_type/c_6501spa
dc.type.coarversionhttp://purl.org/coar/version/c_970fb48d4fbd8a85spa
dc.type.contentTextspa
dc.type.driverinfo:eu-repo/semantics/articlespa
dc.type.redcolhttps://purl.org/redcol/resource_type/WPspa
dc.type.versioninfo:eu-repo/semantics/publishedVersionspa
dspace.entity.typePublication

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