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Multiplatform plasma metabolic and lipid fingerprinting ofbreast cancer: A pilot control-case study in ColombianHispanic women

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dc.contributor.authorCala, Mónica P.
dc.contributor.authorAldana, Julián
dc.contributor.authorMedina, Jessica
dc.contributor.authorSánchez, Julián
dc.contributor.authorWist, Julien
dc.contributor.authorMeesters, Roland J.W.
dc.date.accessioned2022-09-21T19:36:09Z
dc.date.available2022-09-21T19:36:09Z
dc.date.issued2018
dc.description.abstractBreast cancer (BC) is a highly heterogeneous disease associated with metabolic reprogramming. The shifts in the metabolomecaused by BC still lack data from Latin populations of Hispanic origin. In this pilot study, metabolomic and lipidomic approacheswere performed to establish a plasma metabolic fingerprint of Colombian Hispanic women with BC. Data from H-NMR, GC-MSand LC-MS were combined and compared. Statistics showed discrimination between breast cancer and healthy subjects on allanalytical platforms. The differentiating metabolites were involved in glycerolipid, glycerophospholipid, amino acid and fatty acidmetabolism. This study demonstrates the usefulness of multiplatform approaches in metabolic/lipid fingerprinting studies to broadenthe outlook of possible shifts in metabolism. Our findings propose relevant plasma metabolites that could contribute to a betterunderstanding of underlying metabolic shifts driven by BC in women of Colombian Hispanic origin. Particularly, the understanding ofthe up-regulation of long chain fatty acyl carnitines and the down-regulation of cyclic phosphatidic acid (cPA). In addition, themapped metabolic signatures in breast cancer were similar but not identical to those reported for non-Hispanic women, despiteracial differences.eng
dc.format.extent16 p.spa
dc.format.mimetypeapplication/pdfspa
dc.identifier.issn1932-6203spa
dc.identifier.urihttps://repositorio.fucsalud.edu.co/handle/001/3166
dc.language.isoengspa
dc.publisherSan Francisco CA: Public Library of Sciencespa
dc.publisher.placeSan Francisco, California, USspa
dc.relation.citationendpage16spa
dc.relation.citationissue2spa
dc.relation.citationstartpage1spa
dc.relation.citationvolume13spa
dc.relation.ispartofjournalPlos Onespa
dc.rights.accessrightsinfo:eu-repo/semantics/openAccessspa
dc.rights.coarhttp://purl.org/coar/access_right/c_abf2spa
dc.rights.creativecommonsAtribución-NoComercial-SinDerivadas 4.0 Internacional (CC BY-NC-ND 4.0)spa
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/4.0/spa
dc.sourcehttps://journals.plos.org/plosone/article?id=10.1371/journal.pone.0190958spa
dc.subject.decsNeoplasias de la mama
dc.subject.decsMujeres
dc.subject.proposalBreast Neoplasmseng
dc.subject.proposalWomeneng
dc.subject.proposalPlasmaeng
dc.subject.proposalControleng
dc.titleMultiplatform plasma metabolic and lipid fingerprinting ofbreast cancer: A pilot control-case study in ColombianHispanic womeneng
dc.typeArtículo de revistaspa
dc.type.coarhttp://purl.org/coar/resource_type/c_6501spa
dc.type.coarversionhttp://purl.org/coar/version/c_970fb48d4fbd8a85spa
dc.type.contentTextspa
dc.type.driverinfo:eu-repo/semantics/articlespa
dc.type.redcolhttps://purl.org/redcol/resource_type/WPspa
dc.type.versioninfo:eu-repo/semantics/publishedVersionspa
dspace.entity.typePublication

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