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Identifcation of candidate miRNAs in early‑onset and late‑onset prostate cancer by network analysis

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dc.date.accessioned2022-09-21T15:38:52Z
dc.date.available2022-09-21T15:38:52Z
dc.date.issued2020
dc.description.abstractThe incidence of patients under 55 years old diagnosed with Prostate Cancer (EO-PCa) has increased during recent years. The molecular biology of PCa cancer in this group of patients remains unclear. Here, we applied weighted gene coexpression network analysis of the expression of miRNAs from 24 EO-PCa patients (38–45 years) and 25 late-onset PCa patients (LO-PCa, 71–74 years) to identify key miRNAs in EO-PCa patients. In total, 69 diferentially expressed miRNAs were identifed. Specifcally, 26 and 14 miRNAs were exclusively deregulated in young and elderly patients, respectively, and 29 miRNAs were shared. We identifed 20 hub miRNAs for the network built for EO-PCa. Six of these hub miRNAs exhibited prognostic signifcance in relapse‐free or overall survival. Additionally, two of the hub miRNAs were coexpressed with mRNAs of genes previously identifed as deregulated in EO-PCa and in the most aggressive forms of PCa in African-American patients compared with Caucasian patients. These genes are involved in activation of immune response pathways, increased rates of metastasis and poor prognosis in PCa patients. In conclusion, our analysis identifed miRNAs that are potentially important in the molecular pathology of EO-PCa. These genes may serve as biomarkers in EO-PCa and as possible therapeutic targets.eng
dc.format.extent14 p.spa
dc.format.mimetypeapplication/pdfspa
dc.identifier.issn2045-2322spa
dc.identifier.urihttps://repositorio.fucsalud.edu.co/handle/001/3165
dc.language.isoengspa
dc.publisherNature Publishing Groupspa
dc.publisher.placeReino Unidospa
dc.relation.citationissue1spa
dc.relation.citationstartpage12345spa
dc.relation.citationvolume10spa
dc.relation.ispartofjournalScientific reportsspa
dc.rights.accessrightsinfo:eu-repo/semantics/openAccessspa
dc.rights.coarhttp://purl.org/coar/access_right/c_abf2spa
dc.rights.creativecommonsAtribución-NoComercial-SinDerivadas 4.0 Internacional (CC BY-NC-ND 4.0)spa
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/4.0/spa
dc.sourcehttps://www.nature.com/articles/s41598-020-69290-7spa
dc.subject.decsNeoplasias de la Próstata
dc.subject.decsBiomarcadores
dc.subject.decsBiología molecular
dc.subject.decsPacientes
dc.subject.decsSupervivencia
dc.subject.proposalProstatic Neoplasmseng
dc.subject.proposalMicroARNseng
dc.subject.proposalBiomarkerseng
dc.subject.proposalGeneseng
dc.subject.proposalMolecular biologyeng
dc.subject.proposalPatientseng
dc.subject.proposalSurvivorshipeng
dc.titleIdentifcation of candidate miRNAs in early‑onset and late‑onset prostate cancer by network analysiseng
dc.typeArtículo de revistaspa
dc.type.coarhttp://purl.org/coar/resource_type/c_6501spa
dc.type.coarversionhttp://purl.org/coar/version/c_970fb48d4fbd8a85spa
dc.type.contentTextspa
dc.type.driverinfo:eu-repo/semantics/articlespa
dc.type.redcolhttps://purl.org/redcol/resource_type/WPspa
dc.type.versioninfo:eu-repo/semantics/publishedVersionspa
dspace.entity.typePublication

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